Immunology
Essential and Fundamental
Second Edition
Sulabha Pathak and U. Palan
ISBN 978-1-57808-378-7; 2005; 427 pages, pb, 8½ × 10½"; $ 53.80      Buy Now


"This book views Immunology in the context of everyday human life. It challenges scientific imagination by bringing the interested reader sidetracks, digressions as they may seem, that add a different dimension to the subject being discussed. Immunology: Essential and Fundamental constantly reminds the reader that the subject that it gets its name from, although being an extensively specialized field, must be viewed in the context of the human body, the individual, and the society s/he inhabits. It helps us appreciate that Immunology goes beyond being a compartmentalized and specialized field and enriches our understanding of the big picture."


Contents:
. Introduction to Immunology

. Innate Immunity or Non-Adaptive Immunity
Introduction; The Main Players; The Innate Immune Response

. Complement
Introduction; The Classical Pathway; The Lectin Pathway of Complement Activation;
The Alternative Pathway of Complement Activation; Terminal Pathway; Role of Complement
in Health and Disease; Regulation of the Complement Cascade; Complement Receptors

. Entities of the Adaptive Immune Response: Immunogens
Introduction; Immunogens and Antigens; Types of Antigens; Factors Influencing Immunogenicity

. Entities of the Adaptive Immune Response: Lymphoid System
Introduction; Primary Lymphoid Organs; Secondary Lymphoid Organs; The Accessory Cells

. Molecules of Adaptive Immune Recognition: Antigen Recognition Receptors
Introduction; BcR; TcR; Effect of Costimulators on B and T Cell Signal Transduction Pathways

. Molecules of Immune Recognition: Antigen Presenting Molecules
Introduction; MHC Class I Molecules; MHC Class II Molecules; Organisation of MHC Genes;
Polygenism and Polymorphism in the MHC Molecules; CDI

. The Lymphocytes
Introduction; The B Lymphocytes; The T Lymphocytes

. Humoral Immunity
Introduction; Primary Humoral Response; Secondary Humoral Response; Ig Synthesis;
Ig Structure; Classes of Antibodies; Role of Ig in Immunity; Ig Receptors

. Genetic Mechanisms of Immune Diversity
Introduction; V(D)J Recombination; Regulation of V(D)J Recombination; Somatic Hypermutation
and Class Switch Recombination (CSR)

. Cell-Mediated Immunity
Introduction; Mechanisms of Cell-Mediated Cytotoxicity

. Immune Tolerance
Introduction; Central Tolerance; Peripheral Tolerance; Tolerance Induction

. Transplantation Immunology
Introduction; Antigens Involved in Graft Rejection; Allorecognition; Graft Rejection; GVHD;
Immunosuppressive Therapies; Blood Transfusion

. Autoimmunity
Introduction; Interplaying Factors; Triggering Factors; Mechanisms of Damage; Diagnosis and
Treatment

. Hypersensitivity
Introduction; Hypersensitivity type I; Hypersensitivity type II; Hypersensitivity type III;
Hypersensitivity type IV

. Cancer and the Immune System
Introduction; Effectors of Anti-tumour Immunity; Tumour Immune Evasion; Treatment

. AIDS
Introduction; The Virus; HIV and the Immune System; Treatment